Selected Publications: Andres L. Lozano, M.D., Ph.D. FRCS

Fukuda M, Mentis M, Ghilardi MF, Dhawan V, Antonini A, Hammerstad J, Lozano A, Lang A, Lyons K, Koller W, Ghez C, Eidelberg D: Functional correlates of pallidal stimulation for Parkinson’s disease. Annals of Neurology 2001: 49: 155 –164.

Alkhani A, Lozano AM, Pallidotomy for Parkinson disease: a review of contemporary literature.  J Neurosurg, 94, 2001; 43-49.

Deep Brain Stimulation for Parkinson’s Disease Study group (includes AM Lozano) Deep brain stimulation of the subthalamic nucleus or globus pallidus pars interna in Parkinson’s disease.  New England Journal of Medicine, 2001 Aug; 345: 956-963.

Fukuda M, Mentis MJ, Ma Y, Moeller JR, Dhawan V, Antonini A, Lang AE, Lozano AM, Hammerstad J, Lyons K, Koller WC, Eidelberg D: Networks mediating the clinical effects of pallidal brain stimulation for Parkinson’s disease: a PET study of resting-state glucose metabolism.  Brain, 2001 Aug; 124 (Pt 8): 1601-9.

Levy R, Lang AE, Dostrovsky JO, Pahapill P, Romas J, Saint-Cyr J, Hutchison WD, Lozano AM: Lidocaine and Muscimol microinjections in the subthalamic in nucleus reverse Parkinson’s disease.  Brain, 2001 Oct; 124(Pt 10): 2105-2118.

Levy R, Dostrovsky JO, Lang AE, Hutchison WD, Sime E, Lozano AM: The effects of apomorphine on subthalamic nucleus and globus pallidus internus neurons in patients with Parkinson’s disease.  J Neurophysiol. 2001, Jul; 86 (1) 249-260.

Dostrovsky JO, Hutchison WD, Lozano AM.  The Globus Pallidus, Deep Brain Stimulation and Parkinson’s disease.  The Neuroscientist 2002 Jun;8(3):284-90.

Levy R, Hutchison WD, Lozano AM, Dostrovsky JO: Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activity. The Journal of Neuroscience. 2002 Apr 1;22(7): 2855-61.

Lozano AM: Deep brain stimulation: challenges to integrating stimulation technology with human neurobiology, neuroplasticity, and neural repair. J Rehabil Res Dev. 2001 Nov-Dec; 38 (6):x-xix.

Krack P, Dostrovsky J, Ilinsky I, Kultas-Ilinsky K, Lenz F, Lozano A, Vitek J: Surgery of the motor thalamus: Problems with the present nomenclatures. Movement Disorders. 2002 March Vol 17, Suppl. 3 S2-S8.

Levy R, Ashby P, Hutchison WD, Lang AE, Lozano AM, Dostrovsky JO. Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease. Brain, 2002 June; 125 (6) 1196-1209.

Lozano AM, Dostrovsky JO, Chen R, Ashby P. Deep Brain Stimulation for Parkinson’s Disease: Disrupting the disruption. The Lancet Neurology. August 2002: Vol 1(4): 225-231.

Nutt JG, Burchiel KJ, Comella CL, Jankovic J, Lang AE, Laws ER Jr., Lozano AM, Penn RD, Simpson RK, Stacy M, Wooten GF. Randomized, double-blind trial of glial cell lie-derived neurotrophic factor (GDNF) in PD. Neurology. 2003 Jan 14;60(1):69-73.

Lozano AM and Richter E. Surgery for Parkinson’s disease: Where are we? Lancet Neurology (invited review, in press)

Hamani C, Saint-Cyr JA, Fraser J, Kaplitt M, Lozano AM. The subthalamic nucleus in the context of movement disorders. Brain Jan 2004 127(pt 1): 4-20

Lozano AM, Abosch A: Pallidal stimulation for dystonia. Adv Neurology Jan 2004 94: 301-308 Review.

Lozano AM, Kalia S: Progress in Parkinson’s disease. Scientific American (In press)

Moro E, Lang AE, Strafella AP, Poon YY, Arango PM, Dagher A, Hutchison WD, Lozano AM:  Bilateral globus pallidus stimulation for Huntington’s disease.  Ann Neurol 2004 Aug; 56(2): 290-294.

Hanajima R, Chen R, Ashby P, Lozano AM, Hutchison WD, Davis KD, Dostrovsky JO. Very fast oscillations evoked by median nerve stimulation in the human thalamus and subthalamic nucleus. J Neurophysiol. 2004 Dec;92(6):3171-82.

Kalia SK, Lee S, Liu L, Crocker SJ, Thorhildur ET, Smith PD, Glover JR, Fon EA, Park DS, Lozano AM.  BAG5 Inhibits Parkin and enhances dopaminergic neuron degeneration.  Neuron 2004 44:931-945.

Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C,  Schwalb JM and Kennedy SH. Deep Brain Stimulation for Treatment-Resistant Depression.  Neuron 2005 45:651-660.

Kim RH, Smith PD, Aleyasin H, Hayley S, Mount MP, Pownall S, Wakeham A, You-Ten AJ, Kalia SK, Horne P, Westaway D, Lozano AM, Anisman H, Park DS, Mak TW.  Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci USA  2005 102(14):5215-5220

Hamani C, Richter E, Schwalb JM, Lozano AM:  Bilateral subthalamic nucleus stimulation for Parkinson’s disease.  A systematic review of clinical literature. Neurosurgery 2005. 56(6):1313-1324

Rodriguez-Oroz MC, Obeso JA, Lang AE, Houeto JL, Pollak P, Rehncrona S, Kulisevsky J, Albanese A, Volkmann J, Hariz MI, Quinn NP, Speelman JD, Guridi J, Zamarbide I, Gironell A, Molet J, Pascual-Sedano B, Pidoux B, Bonnet AM, Agid Y, Xie J, Benabid AL, Lozano AM, Saint Cyr J, Romito L, Contarino F, Scerrati M, Fraix V, Van Blercom N. Bilateral deep brain stimulation in Parkinson’s Disease: A multicentre study with 4 years follow-up. Brain. June 2005 1-10

Davis KD, Taylor KS, Hutchison WD, Dostrovsky JO, McAndrews MP, Richter EO, Lozano AM. Human anterior cingulate cortex neurons encode cognitive and emotional demands. J Neurosci 2005 Sep 14;25(37):8402-6

Zumsteg D, Lozano AM, Wieser HG, Wennberg RA. Cortical activation with deep brain stimulation of the anterior thalamus for epilepsy. Clin Neurophysiol. 2006 Jan;117(1):192-207.

Wennberg R, Lozano AM. Restating the importance of bipolar recording in subcortical nuclei. Clin Neurophysiol. 2006 Feb;117(2):474-5.

Molnar GF, Sailer A, Gunraj CA, Cunic DI, Wennberg RA, Lozano AM, Chen R. Changes in motor cortex excitability with stimulation of anterior thalamus in epilepsy. Neurology. 2006 Feb 28;66(4):566-71.

Hanajima R, Dostrovsky JO, Lozano AM, Chen R. Dissociation of thalamic high frequency oscillations and slow component of sensory evoked potentials following damage to ascending pathways. Clin Neurophysiol. 2006 Apr;117(4):906-11

Andrade DM, Zumsteg D, Hamani C, Hodaie M, Sarkissian S, Lozano AM, Wennberg RA.  Long-term follow-up of patients with thalamic deep brain stimulation for epilepsy. Neurology. 2006 May 23;66(10):1571-3.

Hamani C, Schwalb JM, Razai A, Dostrovsky J, Davis KD, Lozano AM. Deep brain stimulation for chronic neuropathic pain: Long-term outcome and the incidence of insertional effect. Pain. 2006 Jun 21

Zumsteg D, Lozano AM, Wennberg RA.  Depth electrode recorded cerebral responses with deep brain stimulation of the anterior thalamus for epilepsy. Clin Neurophysiol. 2006 Jul;117(7):1602-9.

Neimat JS, Hamani C, Lozano AM. Neural stimulation for Parkinson's disease: current therapies and future directions. Expert Rev Neurother. 2006 Jan;6(1):101-9.

Hamani C, Dostrovsky JO, Lozano AM. The motor thalamus in neurosurgery. Neurosurgery. 2006 Jan;58(1):146-58.

Coffey RJ, Lozano AM. Neurostimulation for chronic noncancer pain: an evaluation of the clinical evidence and recommendations for future trial designs. J Neurosurg. 2006 Aug;105(2):175-89.

Zumsteg D, Lozano AM, Wennberg RA. Mesial temporal inhibition in a patient with deep brain stimulation of the anterior thalamus for epilepsy. Epilepsia. 2006 Nov;47(11):1958-62.

Hamani C, Lozano AM. Hardware-related complications of deep brain stimulation: a review of the published literature. Stereotact Funct Neurosurg. 2006;84(5-6):248-51.

Hamani C, Neimat J, Lozano AM. Deep brain stimulation for the treatment of Parkinson's disease. J Neural Transm Suppl. 2006;(70):393-9.

Weinberger M, Mahant N, Hutchison WD, Lozano AM, Moro E, Hodaie M, Lang AE, Dostrovsky JO. Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease. J Neurophysiol. 2006 Dec;96(6):3248-56.

Neimat JS, Patil PG, Lozano AM. Novel surgical therapies for Tourette syndrome. J Child Neurol. 2006 Aug;21(8):715-8.

Hodaie M, Cordella R, Lozano AM, Wennberg R, Dostrovsky JO. Bursting activity of neurons in the human anterior thalamic nucleus. Brain Res. 2006 Oct 18;1115(1):1-8.

Zumsteg D, Lozano AM, Wennberg RA. Rhythmic cortical EEG synchronization with low frequency stimulation of the anterior and medial thalamus for epilepsy. Clin Neurophysiol. 2006 Oct;117(10):2272-8.

Hanajima R, Chen R, Ashby P, Lozano AM, Hutchison WD, Davis KD, Dostrovsky JO. Intraoperative recording of the very fast oscillatory activities evoked by median nerve stimulation in the human thalamus. Suppl Clin Neurophysiol. 2006;59:121-6.

Hamani C, Schwalb JM, Rezai AR, Dostrovsky JO, Davis KD, Lozano AM. Deep brain stimulation for chronic neuropathic pain: long-term outcome and the incidence of insertional effect. Pain. 2006 Nov;125(1-2):188-96.

Piboolnurak P, Lang AE, Lozano AM, Miyasaki JM, Saint-Cyr JA, Poon YY, Hutchison WD, Dostrovsky JO, Moro E. Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's disease. Mov Disord. 2007 (In press).

Fawcett AP, Cunic D, Hamani C, Hodaie M, Lozano AM, Chen R, Hutchison WD. Saccade-related potentials recorded from human subthalamic nucleus. Clin Neurophysiol. 2007 Jan;118(1):155-63.

Levy R, Lozano AM, Hutchison WD, Dostrovsky JO. Dual microelectrode technique for deep brain stereotactic surgery in humans. Neurosurgery. 2007 Apr;60(4 Suppl 2):277-83; discussion 283-4.

Tang JK, Mahant N, Cunic D, Chen R, Moro E, Lang AE, Lozano AM, Hutchison WD, Dostrovsky JO. Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia. Exp Neurol. 2007 Apr;204(2):845-8.

Hung SW, Hamani C, Lozano AM, Poon YY, Piboolnurak P, Miyasaki JM, Lang AE, Dostrovsky JO, Hutchison WD, Moro E. Long-term outcome of bilateral pallidal deep brain stimulation for primary cervical dystonia. Neurology. 2007 Feb 6;68(6):457-9.

 Sailer A, Cunic DI, Paradiso GO, Gunraj CA, Wagle-Shukla A, Moro E, Lozano AM, Lang AE, Chen R. Subthalamic nucleus stimulation modulates afferent inhibition in Parkinson disease. Neurology. 2007 Jan 30;68(5):356-63.

Hodaie M, Neimat JS, Lozano AM. The dopaminergic nigrostriatal system and Parkinson's disease: molecular events in development, disease, and cell death, and new therapeutic strategies. Neurosurgery. 2007 Jan;60(1):17-28; discussion 28-30.